There is a wide treatment gap in Indian mental healthcare. This article discusses the treatment gap and the contributing factors, and suggests ways to reduce it. The political (policy perspective), social (stigma, discrimination, and gender), cultural (beliefs, explanations, and help-seeking behaviours), and economic (direct and indirect costs of treatment) factors addressed have long impeded mental healthcare. A policy and research review reflects that mental illness in India contributes significantly to the global occurrence of mental illness. The treatment gap causes substantial losses to individuals, families, society, and the nation. Innovation and capacity building are necessary to develop and implement locally relevant, feasible, and effective community-based mental healthcare models.